effect of chavir (ferulagoangulata) plant powder on liver and blood parameters of japanese quail intoxicated with ccl4

this study aimed to evaluate the antioxidant property of chavir plant on japanese quail intoxicated with carbon tetrachloride (ccl4). eighty, one-d-old japanese quail chicks were randomly allotted to 4 treatments with 4 replicates and 5 chicks in each, using completely randomized design with 2×2 factorial arrangements including 2 levels of chavir powder (0 and 1.5 percent) and ccl4 (0 and 1 ml/kg bw). the experimental period lasted 42 d and during this period feed and water were provided ad libitum. at the end of trial, birds (20 for each treatment) were bled through wing vein to determine blood parameters and hepatic enzymes. in addition, liver samples were taken for histology studies. feed intake and body weight gain at different stages of experiment and feed conversion ratio throughout the experiment influenced by experimental treatments (p<0.05). the chavir plant powder at the level of 1.5 percent significantly elevated blood serum total cholesterol and hdl-cholesterol concentrations (p<0.05), but the increase of blood serum triglyceride and ldl-cholesterollevels were not statistically significant. ccl4 increased blood serum concentrations of ast, alt and alp hepatic enzymes (p<0.05), whereas the combination use of both chavir powder and ccl4 ameliorated the adverse effects of ccl4 on ast and alt liver enzymes (p<0.05). histological results showed that chavir plant powder can protect hepatic tissue against ccl4 poisoning. in general, this study showed that chavir plant powder can reduce the effects of oxidative stress of ccl4.